1 edition of Embryonic and fetal antigens in cancer found in the catalog.
Embryonic and fetal antigens in cancer
|Statement||Edited by N.G. Anderson, J.H. Coggin [et al.]|
|Series||United States. Atomic Energy Commission -- Conf-720208|
|Contributions||Anderson, Norman G. 1919- ed., Coggin, Joseph H., ed., U.S. Atomic Energy Commission.|
|The Physical Object|
|Pagination||vii, 373 p.|
|Number of Pages||373|
Tumor-specific antigens can help the body make an immune response against cancer cells. They may be used as possible targets for targeted therapy or for immunotherapy to help boost the body’s immune system to kill more cancer cells. Tumor-specific antigens may also be used in laboratory tests to help diagnose some types of cancer. The placenta develops throughout the embryonic period and during the first several weeks of the fetal period; placentation is complete by weeks 14– As a fully developed organ, the placenta provides nutrition and excretion, respiration, and endocrine function (Table and Figure ).
Stage-specific embryonic antigens (SSEAs) are cell-surface molecules that exhibit lineage-restricted patterns of expression during development. These antigens provide useful markers for identifying embryonic stem cells and their differentiated by: Carcinoembryonic Antigen (CEA) £ Add to cart. CEA, like AFP, belongs to the group of carcinofetal antigens that are produced during the embryonic and fetal period. CEA is mainly found in the fetal gastrointestinal tract and in fetal serum. It also occurs in slight quantities in intestinal, pancreatic, and hepatic tissue of healthy adults.
Book reviews Book reviews Stäber, H.; Wessly, E.-Ch. Book reviews Ciba Foundation Symposium Fetal Antigens and Cancer. London: Pitman VIII+ pp., several figs. and tabs. Hard bound s There are many hypotheses on the origin of tumours but their mechanisms of them are not yet well understood. A. antigens encoded by genes exclusively expressed by tumors (e.g., viral genes). B. antigens encoded by variant forms of normal genes that are altered by mutation. C. antigens that are expressed at lower than normal levels. D. antigens normally expressed only at certain stages of development. E. antigens that are overexpressed in particular.
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Matteo Adinolfi, in Encyclopedia of Immunology (Second Edition), Other ‘fetal’ antigens. Occasionally fetal antigens are claimed to be expressed on cancer cells, but in several instances these antigens are also present in some normal adult tissues and, accordingly, their presence in cancer cells is the result of an ectopic gene expression.
‘Fetal’ antigens have been claimed to. In human pregnancy, fetal antigens elicit both the cellular and humoral maternal immune systems. Maternal T cells against paternally-inherited fetal minor antigens expand in some women when a minor antigen mismatch exists, provided that she possesses the HLA that can present the antigen; these T cells can persist for decades (1, 9, 27, 28).Cited by: Fetal antigens and cancer.
London: Pitman ; Summit, NJ: Distributed in North America by CIBA Pharmaceutical Co., Medical Education Administration, (OCoLC) Online version: Fetal antigens and cancer.
London: Pitman ; Summit, NJ: Distributed in North America by CIBA Pharmaceutical Co., Medical Education Administration, Called vol. 2 in continuation of the Proceedings of the first meeting, called Conference and Workshop on Embryonic and Fetal Antigens in Cancer. Description: vii, pages illustrations.
Series Title: U.S. Atomic Energy Commission. Conf- Other Titles: Proceedings of the second conference on embryonic and fetal antigens in cancer. Pearson G, Freeman G. Evidence suggesting a relationship between polyoma virus-induced transplantation antigen and normal embryonic antigen.
Cancer Res. Sep; 28 (9)– Stonehill EH, Bendich A. Retrogenetic expression: the reappearance of embryonal antigens in cancer cells. Nature. Oct 24; ()– Central nervous system (CNS) embryonal tumors may begin in embryonic (fetal) cells that remain in the brain after birth.
There are different types of CNS embryonal tumors. Pineoblastomas form in cells of the pineal gland. Certain genetic conditions increase the risk of childhood CNS embryonal tumors.
Signs and symptoms of childhood CNS. Fetal Antigens and Cancer [Ciba Foundation] on *FREE* shipping on qualifying offers.
Antigens have been identified in most of the human cancers, including Burkitt lymphoma, neuroblastoma, melanoma, osteosarcoma, renal cell carcinoma, breast cancer, prostate cancer, lung carcinoma, and colon cancer. A key role of the immune system is detection of these antigens to permit subsequent targeting for eradication.
Oncofetal antigens are proteins which are typically present only during fetal development but are found in adults with certain kinds of proteins are often measurable in the blood of individuals with cancer and may be used to both diagnose and follow treatment of the tumors.
VARIOUS reports of embryonal antigens in extracts of tumour tissues have appeared since (refs. 1–9). Such antigens, absent from homologous normal tissues, have been detected in.
Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host. Tumor antigens are useful tumor markers in identifying tumor cells with diagnostic tests and are potential candidates for use in cancer therapy. The field of cancer immunology studies such topics.
1 Mechanism of tumor antigenesis. Throughout this chapter, we will express embryonic and fetal ages in terms of weeks from fertilization, commonly called conception. The period of time required for full development of a fetus in utero is referred to as gestation (gestare = “to carry” or “to bear”).
It. The prospect has arisen that many and perhaps all cancers share antigens commonly present on the developing fetal membranes and that retrogenic phasing may be essential to the malignant process. Several major forms of human cancer have embryonic constituents reexpressed as exemplified by the alphafeto-protein of hepatomas or the Cited by: 9.
In this article, Professor Alexander discusses the role played by onco-foetal antigens. oncofetal antigen: [ an´tĭ-jen ] any substance capable, under appropriate conditions, of inducing a specific immune response and reacting with the products of that response; that is, with specific antibody or specifically sensitized T lymphocytes, or both.
Antigens may be soluble substances, such as toxins and foreign proteins, or. This is a PDF-only article. The first page of the PDF of this article appears : A Munro Neville. You might be surprised to know that a group at Stanford reported a successful anti-cancer vaccine in a animal breast cancer xenograft model.(1)() Instead of embryonic cells, Dr Wu used adult cells induced to form pluri potent stem cells, which are very similar to embryonic stem cells.(1)(6,7) Others have created similar successful vaccines.
tumorigenesis, it seems plausible to infer that onco-fetal antigens perhaps provide an advantage for transformed cells, and the expression of embryonic genes in cancer gives credence to the claim that they are perhaps one of the driving forces of tumorigenesis.
Tumor-associated developmental antigens or onco-fetal antigens These include alpha-fetoprotein (AFP) and carcino-embryonic antigen (CEA) found secreted in the serum. AFP is found in patients with hepatocellular carcinoma whereas CEA is found in colon cancer.
These are important in diagnosis. Cancer/testis (CT) antigens, of which more than 40 have now been identified, are encoded by genes that are normally expressed only in the human germ line, but are also expressed in various tumour.
Any antigens present during the period of lymphoid development are exposed to the immune system so the immune system learns to identify and recognise these as .oncofetal antigens are expressed by cells during certain stages of embryonic from NURS at Harding University.• Cancer/testis (CT) antigens are normally expressed by ga metes and trophoblasts, and are aberrantly expressed in a range of human cancers.
• So far, 44 distinct CT-antigen families, some of which have multiple members, have been Size: KB.